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By Pendulum Therapeutics
$71.24
Capsule
30
August 31, 2026
Pendulum GLP-1 Probiotic is a dietary supplement. It is not FDA-approved, has not been reviewed for safety or effectiveness before sale, and is not a treatment for any disease. It is not equivalent to and does not replace prescription semaglutide or tirzepatide. No claim on this page should be read as a promise of weight loss.
Pendulum Therapeutics is the best-known name in the Akkermansia probiotic niche and effectively created this category. Its GLP-1 Probiotic contains Akkermansia muciniphila, Clostridium butyricum and Bifidobacterium infantis.
Pendulum positions the formulation around postbiotic production — its material describes A. muciniphila generating propionate and a compound it calls p9 to support GLP-1 production, with C. butyricum contributing butyrate.
It is the premium option in this niche. Independent reviewers note Pendulum is generally expensive on one-time purchases, and the GLP-1 Probiotic lists around $74.99 with a 4.2-star average from over a thousand Amazon ratings at the time of review.
Serving size: See label · 30 servings per container
| Ingredient | Amount | % DV |
|---|---|---|
| Akkermansia muciniphila | Amount not publicly broken out | Daily Value not established |
| Clostridium butyricum | Amount not publicly broken out | Daily Value not established |
| Bifidobacterium infantis | Amount not publicly broken out | Daily Value not established |
| Prebiotic componentPublished analysis of Pendulum products notes chicory inulin and oligofructose among the ingredients. | Not publicly listed | — |
Published analysis notes hypromellose (vegetarian capsule) among other ingredients. Consult the current label for the full list.
Marketed for gut health, gut-lining support and metabolic health, with the GLP-1 Probiotic positioned around appetite control support.
Pendulum describes A. muciniphila as reinforcing the mucin layer of the gut lining and reducing permeability, and its GLP-1 Probiotic PRO material describes A. muciniphila generating the postbiotics propionate and p9 to support GLP-1 production, alongside C. butyricum.
Human research has found a negative correlation between A. muciniphila abundance and overweight and obesity, with a proof-of-concept human supplementation study in overweight and obese participants. It is widely described in review literature as a promising next-generation probiotic for metabolic conditions.
Research indicates C. butyricum increased GLP-1 secretion from intestinal L cells, putatively via butyrate production — mechanistically documented but largely in preclinical models.
Pendulum markets the product as third-party tested, which is a meaningful quality signal in a category with no pre-market regulatory review.
As with the rest of this category, we could not identify a published peer-reviewed clinical trial of this finished product demonstrating weight loss. Pendulum publishes customer-reported outcomes (for example, 77% reporting improved gut health on its Akkermansia product), which are self-reported survey data rather than controlled trial results. Strain quantities are not publicly broken out, limiting comparison against studied doses.
Follow the current product label. Pendulum's Akkermansia product is listed elsewhere at two capsules daily; confirm dosing for the GLP-1 Probiotic on the label you receive.
Standard probiotic cautions apply. Consult a physician before use if you are pregnant, nursing, immunocompromised, taking immunosuppressive therapy, or have a known medical condition. Follow the label.
Not publicly listed in the material we reviewed. Check the current label.
Amazon list price at time of review
iHerb listing at time of review
Listed at around $76 in independent review coverage
Pendulum offers subscription pricing on its own site; independent reviewers note one-time purchase pricing is comparatively expensive. Confirm current terms at checkout.
Not publicly confirmed in the material we reviewed. Check Pendulum's current policy before ordering.
Shipped from Pendulum or the retailer you order through. Live probiotics generally benefit from temperature-controlled handling — check the shipping method your retailer uses.
Pricing reflects what Pendulum Therapeutics and named third-party retailers published as of August 31, 2026. Supplement pricing changes frequently — confirm at checkout.
People who want the category-defining brand and value the third-party testing and wider retail availability enough to pay the premium over cheaper formulations with the same strains.
You are immunocompromised or on immunosuppressive therapy, pregnant or breastfeeding, or under 18 without clinician guidance. Also skip it if price matters and you are comfortable with a less established brand carrying the same three strains.
It contains Akkermansia muciniphila, Clostridium butyricum and Bifidobacterium infantis. Published analysis of Pendulum products also notes chicory inulin and oligofructose among the ingredients, with hypromellose used for the vegetarian capsule. Individual strain quantities are not publicly broken out.
It listed at $74.99 on Amazon and $71.24 at iHerb at the time of this review. Pendulum's separate Akkermansia product is listed around $76 in independent review coverage. Subscription pricing is available on Pendulum's own site.
Pendulum describes A. muciniphila as generating postbiotics including propionate and a compound it calls p9 to support GLP-1 production, and research does indicate C. butyricum increased GLP-1 secretion from intestinal L cells via butyrate. That mechanism is documented, but predominantly in preclinical models, and we could not identify a published clinical trial of the finished product showing weight loss.
That depends on what you are paying for. It is the best-established brand, is marketed as third-party tested, and has substantial public review volume. But CoreAge Rx contains the same three strains at $49 a bottle. If brand track record and third-party testing matter most to you, the premium is defensible; if the strain list is what you are buying, it is not obviously so.
Pendulum markets its products as third-party tested. In a category with no pre-market regulatory review and a documented adulteration problem, independent verification is one of the more useful quality signals available.
Every ingredient, dose, price and policy on this page traces to one of these, checked August 31, 2026.
Speak to a qualified healthcare provider or pharmacist before starting this or any supplement — particularly if you take prescription medication, are pregnant or breastfeeding, are immunocompromised, have a chronic condition, or are already taking a GLP-1. A pharmacist can screen your full medication list for interactions in a few minutes, and that is worth doing before you spend anything.
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These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not FDA-approved, are not reviewed for safety or effectiveness before sale, and are not intended to diagnose, treat, cure, or prevent any disease. Nothing on this page is a substitute for prescription medication, and no supplement described here has been shown to produce weight loss comparable to a prescription GLP-1 medication. Individual results vary. Supplements can interact with prescription medications — talk to a qualified healthcare provider or pharmacist before starting anything, particularly if you are pregnant, breastfeeding, immunocompromised, taking other medication, or already on a GLP-1.
This page contains affiliate links, and we may earn compensation if you use them. Last reviewed: August 30, 2026